How Selective Blood Purification Therapies Are Changing Modern Medicine
In recent decades, medicine has made tremendous progress in treating complex diseases that were once considered very difficult to manage. One of the most promising fields is selective blood purification therapies — innovative methods that go far beyond traditional dialysis or plasma exchange.
At DnTripleD, we follow these developments closely because they are transforming how patients with autoimmune, metabolic, neurological, rheumatological and post-viral conditions are treated worldwide. As the exclusive distributor of Medica S.p.A. blood purification technologies in Poland, we see first-hand how these treatments are changing patients’ lives — restoring health, reducing symptoms, and giving hope where steroids and other medications often reach their limits.
From plasma exchange to selective apheresis
The evolution of blood purification therapies began decades ago with plasma exchange (plasmapheresis), a procedure in which part of blood plasma is removed and replaced with donor plasma or substitute fluids. While effective in certain cases, this method was a broad, non-selective intervention.
In the 1980s, Japan pioneered the development of selective apheresis. The main goal was to design systems that could remove specific pathogenic particles based on their molecular weight or the molecular weight of larger proteins that they are bound to, instead of filtering out all plasma components.
This shift from general to highly selective therapy marked a turning point — making blood purification treatments safer, more precise, and better tolerated by patients.
Technology for safety
Modern blood purification devices are not only more efficient but also far safer than before. In contrast to earlier systems that relied on centrifuges to separate blood components, today’s therapies use high-precision filters. This allows doctors in many cases to use only peripheral vein access and makes the process gentler, faster, and more selective.
Thanks to world-class manufacturers and international safety standards, modern machines such as AFERsmart PLUS™ manufactured by Medica S.p.A. (Italy) are equipped with multiple protective sensors and smart software.
These innovations not only reduce risks but also make treatments accessible to patients with complex health conditions.
Applications in modern medicine
Selective blood purification is now used worldwide for a growing list of health conditions:
• Autoimmune diseases (e.g. myasthenia gravis, vasculitis, lupus, endometriosis)
• Lipid disorders (familial hypercholesterolemia)
• Post-viral syndromes such as long-COVID
• Chronic fatigue syndrome and inflammatory conditions
• Neurological diseases where autoantibodies play a role
Patients report improvements in energy, cognitive clarity, and reduction of symptoms after undergoing therapy.
The growing industry of filters and cartridges
The industry of selective fractionator and adsorption filters is rapidly growing. The aim is to design increasingly specialized tools that can selectively remove harmful particles — from antibodies and cytokines to cholesterol complexes.
One of the most exciting frontiers is the removal of microplastics from the blood. Recent research (https://pmc.ncbi.nlm.nih.gov/articles/PMC12162106/) shows that microscopic plastic particles are entering the human body through food, water, and air. The latest developments in filter technology open the possibility of addressing this emerging health challenge, marking another step forward in preventive and personalized medicine.
Conclusion
Advanced blood purification therapies represent a new era in medicine: safer, more precise, and more effective. What began with simple plasma exchange has evolved into highly selective treatments capable of targeting specific disease mechanisms.
At DnTripleD, we are proud to have brought the latest generation of Medica S.p.A. blood purification technologies to Poland. By combining cutting-edge Italian innovation from Medica S.p.A. with global medical expertise confirmed by American and German guidelines for therapeutic apheresis, these therapies are changing patient lives.