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We are increasing access to plasmapheresis in Poland as first-line treatment in outpatient setting

Double Filtration Plasmapheresis (DFPP):

Highly efficient treatment for 70+ diseases. Can be performed in outpatient setting

DFPP is highly efficient for over 70 diseases and conditions including autoimmune conditions, multiple sclerosis, Alzheimer's disease, myasthenia gravis, systemic lupus, rheumatoid arthritis, kidney diseases, atherosclerosis, diabetes complications, obesity, long COVID, allergies, chronic fatigue syndrome, and heavy metal toxicity. DFPP is also used in longevity medicine and in-vitro fertilization treatments. DFPP has a strong anti-inflammatory and healing effects.

DFPP is approved in the US, Germany, Japan, Canada, and other countries. International research confirms it's efficiency.

Clinics around the world are launching DFPP in outpatient setting, and we have brought this technology to Poland.

Treatment Benefits

  • Non-invasive outpatient procedure
  • No need for donor blood or albumin
  • Selective removal of harmful substances
  • Preserves essential blood components
  • Effective for treatment-resistant conditions
  • Quick recovery with minimal downtime

Key Advantages of DFPP

  1. 1
    DFPP uses advanced membrane filtration (not centrifuges) to separate blood components, and is therefore much safer. 

  2. 2

    Requires only arm vein access (no neck catheter needed) - treatments are completely outpatient.
  3. 3
    Unlike traditional plasmapheresis that discards plasma, DFPP's second-stage filter removes only harmful substances, returning clean plasma to the patient. No need for donor blood or albumin.

About Us

DnTripleD sp. z o.o. is the exclusive distributor of Medica S.p.A. (Italy) blood purification equipment and filters in Poland. We are committed to making DFPP, Hemoperfusion and other methods of plasmapheresis more accessible in Poland.


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5 Treatments with AFERsmart Plus™ system

The AFERsmart PLUS™ system can work in outpatient or hospital setting and can perform five types of plasmapheresis, including:

  1. Double Filtration Plasmapheresis, DFPP: performed through arm veins in outpatient conditions. Does not require donor plasma.
  2. Hemoperfusion: performed through neck veins. Does not require donor plasma. 
  3. Traditional plasma exchange (therapeutic plasmapheresis): part of plasma is discarded and replated with donor plasma/albumin
  4. Selective apheresis - used for example in organ transplant rejection
  5. Double Filtration Adsorption - used for patients with septic shock.

1. Double Filtration Plasmapheresis (DFPP)

Double Filtration Plasmapheresis (DFPP) 

An advanced therapeutic approach for treating various autoimmune and inflammatory conditions. You need only arm vein access. No donor plasma or albumin needed.

Double Filtration Plasmapheresis

Treatment 

Double Filtration Plasmapheresis (DFPP, Double Filtration Apheresis): 

  1. For each patient they install a sterile single-use set. There is no contact between the machine and the blood, the blood goes only through the sterile set. 
  2. The machine washes the single-use set with saline to remove air.
  3. The doctor administers anticoagulant such as heparine.
  4. The patient is connected to the system through arm veins. The machine takes the blood.
  5. The first filter separates the blood into plasma and red blood cells. Red blood cells are immediately returned to the body. Plasma is heated and sent to the second filter which removes antibodies, cytokines, cholesterol, pathogenic immune complexes, heavy metals, and toxins.
  6. Clean plasma is returned to the body with saline. Dirty plasma is collected in a bag and can be sent to laboratory. 

 

We offer a choice of filters manufactured by Medica S.p.A.: three types of filters target LDL, different types of antibodies and other substances. 

Because the patient loses a very small volume of plasma, no donor plasma and no albumin replacement is required. DFPP can be performed in an ambulatory setting. 

DFPP is indicated for patients with various diseases across multiple medical specialties:

Rheumatology

  • Systemic lupus erythematosus
  • Rheumatoid arthritis
  • Systemic scleroderma
  • Allergic vasculitis
  • Hemorrhagic vasculitis
  • Polyarteritis nodosa
  • Dermatomyositis

Cardiology & Vascular Surgery

  • Viral myocarditis
  • Angina pectoris
  • Post-infarction syndromes
  • Carditis in connective tissue diseases
  • Systemic atherosclerosis
  • Coronary heart disease
  • Dyslipidemia

Neurology

  • Multiple sclerosis
  • Myasthenia gravis
  • Allergic encephalitis
  • CNS demyelinating diseases
  • Slow-progressing viral CNS infections
  • Alzheimer's disease

Endocrinology

  • Metabolic syndrome
  • Diabetes and its complications
  • Insulin sensitization
  • Hashimoto's autoimmune thyroiditis
  • Addison's disease

Gastroenterology

  • Crohn's disease
  • Ulcerative colitis
  • Hepatitis treatment
  • Fatty liver disease

Nephrology

  • Chronic kidney diseases
  • Lupus nephritis
  • Henoch-Schönlein purpura
  • Hemorrhagic vasculitis
  • Goodpasture syndrome
  • Paraproteinemia

Dermatology

  • Dermatitis and dermatoses
  • Psoriasis
  • Rosacea treatment
  • Pemphigus
  • Acne
  • Toxicodermia

Ophthalmology

  • Endocrine ophthalmopathy
  • Uveitis
  • Pseudotumor
  • Diabetic retinopathy

Allergology

  • Hay fever
  • Atopic dermatitis
  • Urticaria
  • Physical allergies
  • Hypersensitivity reactions

Pulmonology

  • Fibrosing alveolitis
  • Bronchial asthma
  • Treatment of chronic lung diseases

Viral Diseases

  • Cytomegalovirus
  • Hepatitis
  • Viral skin diseases
  • Post-viral infection intoxication

Obstetrics & Gynecology

  • Ovarian hyperstimulation syndrome
  • Complex treatment of genital infections
  • Climacteric syndrome
  • IVF preparation

Benefits and Effects

DFPP Removes or Reduces:

  • Autoantibodies against nerve structures
  • Circulating pathogenic immune complexes
  • Abnormal haptens (heavy metals/pesticides)
  • Abnormal antibodies/paraproteins
  • Rheumatoid antibodies
  • Autoantibodies against connective tissue
  • Virus particles (including hepatitis C and HIV)

Other DFPP Effects:

  • Increased oxygen pressure in tissues
  • Optimization of blood flow properties
  • Elevation of reduced mitochondrial ATP
  • Reduction of nitrosative and oxidative stress

2. Plasmapheresis (Therapeutic Plasma Exchange)

Therapeutic Plasma Exchange

Traditional plasmapheresis to remove part of plasma together with toxic substances. Requires donor plasma/albumin. 

What is Therapeutic Plasma Exchange?

Therapeutic Plasma Exchange (TPE, also known as Therapeutic Apheresis or Therapeutic Plasmapheresis) is a medical procedure designed to remove harmful substances from the blood's plasma component:  the separated plasma is completely discarded and replaced with an albumin solution, fresh frozen plasma or plasma derivatives.

In contrast to Double Filtration Plasmapheresis which selectively removes harmful substances, TPE is a non-selective treatment. 

Because TPE requires plasma replacement, it is performed in hospitals. 

Substances Removed by TPE

  • Pathogen autoantibodies
  • Immune complexes
  • Cryoglobulins
  • Endotoxins
  • Cholesterol-containing lipoproteins
Therapeutic Plasma Exchange Treatment

Target Population

Therapeutic Plasma Exchange (TPE) treatment is indicated for patients affected by various diseases, including:

  • Vasculitis (Goodpasture syndrome and Wegener syndrome)
  • Thrombotic thrombocytopenic purpura (TTP)
  • Cryoglobulinemia
  • Micromolecular and macromolecular myeloma
  • Lupus erythematosus
  • Hemolytic uremic syndrome
  • Guillain-Barré syndrome

3. Hemoperfusion

Hemoperfusion

Advanced blood purification therapy for removing toxins and inflammatory mediators. Uses whole blood (not plasma like in  DFPP). For hemoperfusion you need neck vein access, because the procedure requires strong blood flow.  

What is Hemoperfusion?

Hemoperfusion (HP) is a medical treatment that involves passing the patient's blood through a device containing an adsorbent material that removes toxic substances. 

Hemoperfusion is performed through neck veins. 

Because the patient loses only a small volume of blood in the filter, no donor plasma is required. 

What Hemoperfusion Removes

  • Pro- and anti-inflammatory mediators
  • Apo-B lipoproteins [e.g. LDL, Lp(a)]
  • B-2 Microglobulin
  • High levels of cytokines
  • Elevated bilirubin
  • Myoglobin

Treatment Applications

  • Sepsis / Severe Sepsis / Septic Shock
  • Multiple Organ Failure Syndrome (MOF)
  • Familial Hypercholesterolemia
  • Dialysis-Related Amyloidosis (DRA)
  • Lp(a) Hyperlipoproteinemia
  • Systemic Inflammatory Response Syndrome (SIRS)
  • Treatment of rhabdomyolysis
  • Hyperbilirubinemia
  • In Germany used as a support therapy for patients undergoing chemotherapy 
Hemoperfusion Treatment

Benefits of Hemoperfusion

  • Targeted removal: Selectively eliminates specific toxins and inflammatory mediators
  • Rapid action: Provides quick reduction of harmful substances in critical conditions
  • Complementary therapy: Can be used alongside other treatments for enhanced results
  • Customizable approach: Treatment parameters (the filter) can be adjusted based on patient needs
  • Broad application: Effective for multiple medical conditions across different specialties

4. Double Filtration Apheresis with Adsorption

Adsorption Treatment

Helps regulate the immune response in critically ill patients (septic shock, cytokine storm, multiple organ dysfunction)

What is Adsorption Treatment?

The treatment works by passing blood through special adsorption columns containing materials that selectively bind to and remove harmful molecules while preserving essential blood components.

Key Benefits

Selectively removes cytokines that drive inflammation without affecting beneficial blood components. Provides rapid improvement in hemodynamic parameters and helps restore normal immune function.

Treatment Process

Blood is drawn from the patient, passed through specialized adsorption columns that capture inflammatory mediators, and then returned to the patient. The process typically takes 4-6 hours per session.

Adsorption Treatment

Septic Shock

Helps stabilize patients experiencing septic shock by removing excess cytokines

Cytokine Storm

Effective in managing cytokine storm conditions in critically ill patients

Systemic Inflammation

Reduces systemic inflammatory response in various critical conditions

Multi-Organ Support

Provides support for patients experiencing multiple organ dysfunction

5. Selective Apheresis

Selective Apheresis Treatment

Advanced targeted therapy for removing specific harmful substances from the bloodstream

Leczenie Selektywną Aferezą

What Selective Apheresis Removes

Selective apheresis treatment can be used to remove or reduce:

  • Apo-B-containing lipoproteins [example: LDL, Lp(a)]
  • Inflammatory mediators
  • Anti-DNA antibodies
  • Anti-cardiolipin
  • Immune complexes

Target Population

This treatment is indicated for patients with multiple pathologies, including:

  • Familial hypercholesterolemia
  • Peripheral arterial occlusive syndrome
  • Focal segmental glomerulosclerosis
  • Systemic lupus erythematosus
  • Goodpasture's syndrome
  • Cryoglobulinemia
  • Thrombotic thrombocytopenic purpura (TTP)
  • Devic's neuromyelitis optica

Transplantation Applications

  • HLA-incompatible transplantation
  • AB0-incompatible blood group transplantation
  • Acute antibody-mediated rejection

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Employment at DnTripleD

We are open to recruiting doctors (specialties: anaesthesiology, intensive care, vascular surgery) and nurses. We will provide training on double filtration plasmapheresis and related treatments. 

Please send your CV at info@dnripled.pl

Note: All information on this website is for informational purposes only. Please consult with your healthcare provider.